A strange celestial phenomenon heralds the return of 4400 people, all of whom were thought to be dead as they vanished over a period of 60 years. What's even weirder that none of them remembers what happened to them or how they are still the same age they were at their disappearance.
As the strange behavior of the returned 4400 attracts notice, one of them employes his enhanced abilities to become a crime fighter.
As the public learns of the identities of the 4400, Baldwin and Skouris try to stop a returnee, Oliver Knox, who has been using his abilities to induce murders.
In the aftermath of the leaks about the 4400, they become the victims of terrorist attacks that claim the lives of several of them. Baldwin and Skouris race against time to identify the culprits before they can kill any more.
Baldwin and Skouris attempt to save Kyle from the clutches of agent Lytell. Baldwin finds out the truth about what happened to the 4400.