The production crew made sure Abigail Breslin really was listening to music in her headphones to keep her from hearing Alan Arkin's profanity-laced scenes.
When writing the script, Arndt chose the Volkswagen T2 Microbus to use for the road trip based on his experience with the vehicle and its practicality for filming: "I remember thinking, it's a road trip, what vehicle are you going to put them in? And [the] VW bus just seems logical, just because you have these high ceilings and these clean sight lines where you can put the camera. In the front windshield looking back and seeing everybody." Five VW Microbuses were used for the family car as some were modified for different filming techniques.
Abigail Breslin got nominated for best actress in a supporting role for her performance in this movie
The movie took five years to make, mostly due to financial reasons