In order to fulfil their craving for White Castle burgers, a Korean-American office worker and his Indian-American pothead friend set out on a trip. However, their route to the restaurant is loaded with unexpected challenges.
On the way to Amsterdam, stoners Harold and Kumar are mistaken for terrorists and sent to Guantanamo Bay. After a successful escape, their attempt to prove their innocence leads them to Texas to enlist the help of the influential Colton Graham who just happens to be Kumar's ex's new fiancé.
When they accidentally destroy the prized tree of Harold's father-in-law, friends Harold and Kumar embark on a journey across New York to find the perfect replacement tree.