The events revolve around the lives of a group of teenagers on the East Side of New York, including Serena van der Woodsen, Blair Waldorf, and Nate Archibald, and the many strange events and actions that the trio witnesses in their lives.
The young and wealthy elite living in New York City find it difficult to hide the details of their lives. Blair thinks she has the perfect relationship, but Chuck has a cunning plan for her, while Dan and Serena are forced to work out their issues while being stuck in an elevator.
The young and rich elite strive for a perfect life, but things don't go as planned. Serena and Carter's relationship begins to become tense, while Blair gets used to her married life with Chuck.
While Chuck is in Prague getting better after what happened, Serena and Blair are on vacation in Paris. Nate meets a girl named Juliet Sharp, and she might end up being the girl he wants to date.
As Blair plans her wedding, she has to reckon with her feelings for Chuck, which brings about unforeseen tragic consequences. Meanwhile, Serena tries to prove herself on the movie set and decide on the direction she wants her life to take.
The adventures of four girls who were subjected to blackmail continue. As Blair prepares to launch her new fashion line, Serena hosts a big party, and her friend Dan has to decide if he is willing to give up his integrity in order for his work to get published.