After the catastrophic food storm in the first part, Flint and his friends are forced to leave town. Flint joins The Live Corp Company that's tasked with cleaning the island. Flint discovers that his device still works, creating mutant food monsters, and he and his friends decide to return to save the world.
Inventor Flint Lockwood is finally getting his due: he’s been invited to join his idol Chester V’s The Live Corp Company, which brings together the greatest minds to invent new technologies for the betterment of mankind. When Chester discovers his famous machine, which turns water into food, is still working and pumping out food-animal hybrids, an epic mission to save the world commences!