Uncle Grandpa, a friendly creature with the ability to take many forms, visits kids in their homes to check on them and help them with their troubles.
As a big-bellied child finds it hard to put on his shirt, Uncle Grandpa takes him on an adventure in an attempt to comfort him and show him that being big-bellied has its advantages.
While coming to a child's aid, Uncle Grandpa discovers that Giant Realistic Flying Tiger has disappeared, whereupon he sets out to look for her.
Uncle Grandpa mistakenly believes a child called Melvin to be a space emperor, so he dispatches him to another dimension, but when he realizes that he made a mistake, Uncle Grandpa sets out to rescue Melvin.
After the funny face that Uncle Grandpa created comes to life and begins to destroy the RV and scare everyone in it, Mr. Gus comes to their rescue.
As an urgent situation arises, Uncle Grandpa and his friend set out to buy some moustache cream, but things don't go as planned.
As a child named Eric seeks to get a hip nickname, Uncle Grandpa informs him that through some yard work he can do so.
As a teenage girl tries to get her drivers' license, Uncle Grandpa comes to her aid.
When Mr. Gus and Pizza Steve fail to find a sitter for Uncle Grandpa, the latter decides to make a copy of himself to look after him in his friends' absence.
As he inadvertently eats the homework of a kid called Dennis, Uncle Grandpa attempts to make amends for what he did; however, things get out of hand when he brings a mummy to life.
With his head stuck in a jar, Uncle Grandpa is unable to come to the aid of a kid called Guillermo, whereupon Mr. Gus and Pizza Steve take it upon themselves to fill UG's shoes and help Guillermo.
As Susie is afraid of the dark, she embarks on an adventure with Uncle Grandpa, who turns out to have the same problem, in an attempt to get over their fear.
As they don't have enough money to pay for the food they ate at a restaurant, Uncle Grandpa and his friends stumble upon a treasure map, which they believe will save them from trouble.
With Uncle Grandpa and Belly Bag locked out of the RV, they attempt to find a solution to this problem.
Mr. Gus ends up wearing a tight-fitting pair of denim shorts, which causes him to feel self-conscious, and as his friends get into trouble, he seeks to take off his shorts so that he can come to their aid.
In the hope of assisting a boy called Adam in trouncing a video game, Uncle Grandpa and Pizza Steve must find their way into Adam's head and take control of his brain.
A strange and irking noise prevents the gang from sleeping during Sleepover Dream Night, which affects their lucidity.
As they run into a dog called Charlie Burgers who lost his ball, Uncle Grandpa and the gang decide to do whatever it takes to help him get his ball back.
An episode that comprises a set of shorts that depict different adventures by Uncle Grandpa and his friends, including hosting a news show, a couple of turtles talking about what is hip and what is stupid, and Uncle Grandpa's frantic attempt to break open a piñata.
As Uncle Grandpa transforms a kid named Austin into a robot so that he can be perfect, things get out of hand when the robotic Austin realizes that Uncle Grandpa is not perfect and attempts to do away with him.
As a Japanese kid named Akira wants to create a monster film, Uncle Grandpa and his pals head to Japan to assist him.
Since Uncle Grandpa and Mr. Gus can't agree on what to watch on TV, Pizza Steve suggests that they settle the argument by having a leg wrestling contest.
After Uncle Grandpa comes back from the future with a message to the effect that Pizza Steve will carry out a deed that will hurt his feelings, this information starts preying on Pizza Steve's mind.
A set of shorts that feature different stories, including a tour of Uncle Grandpa's RV, Uncle Grandpa's purchase of a copy of his beloved comic book, Weird Man, and a fierce face-off between Pizza Steve and a spaghetti and meatball monster.
Uncle Grandpa and his friends get in over their heads after Kev, the viewer who was chosen to draw the exploits of the gang in the latest episode, decides to create various monsters for them to face.
As Uncle Grandpa's day starts off badly, he gets into a bad mood, whereupon his loyal friends, Pizza Steve, Mr. Gus, and Giant Realistic Flying Tiger, try to make him feel better.
With a prank war going on between Pizza Steve and Mr. Gus, the latter decides to pull the ultimate prank; however, he discovers that his friend might wind up being eaten as a result of his reckless action.
Uncle Grandpa finds himself in a pickle as he sends some pants back to the year 1492 instead of 1992, whereupon he sets out to fix the situation.
A misunderstanding causes Uncle Grandpa to dispatch Pizza Steve to the moon so that he can become Pizza Steve's best buddy.
In an attempt to get enough money to buy a jet, Pizza Steve talks Uncle Grandpa into launching a food truck; however, things don't go as planned.
As Uncle Grandpa's friends attempt to convince him that hide-and-seek is not such a bad game, things get out of hand when he is unable to locate them, which causes him to recall a dark memory.
A reminiscence of a historic wrestling game called the Nuttiest Match Ever, in which the icons Chicken Man, The Best, and Mysterious Gus made history by winning all of the matches they participated in.
When Uncle Grandpa learns that Belly Bag is suffering from a baffling sickness, he sets out on a mission inside Belly Bag to determine the cause of his pal's condition.
Stressed out by his constant endeavors to help kids, Uncle Grandpa seeks to take a vacation, which he soon realizes is out of the question.
Aunt Grandma is an evil trickster who seeks to make Uncle Grandpa outmoded, so he decides to take her on with his friends' help.
After Uncle Grandpa comes to a teenager's aid so that he can attend a party, he discovers that the kid has been grounded, whereupon he sets out to right his wrong.
On Halloween, Uncle Grandpa decides to turn the RV into a haunted house. As some teenage kids visit it, UG tries to make the RV appear spookier, but things don't go as planned, so he attempts to enter the RV and rescue the kids.
After uploading a video on the Internet, Uncle Grandpa finds that someone disliked it. As Mr. Gus assures UG that it's just an Internet troll, UG believes that it's an actual troll, whereupon he sets out to vanquish him.
As a girl called Jacqueline doesn't consider Uncle Grandpa's jokes funny, he tries to get to the bottom of the problem and discovers that her lack of a sense of humor is caused by some evil monster living inside her, so he decides to help her.
Mr. Gus and Pizza Steve end up in an intergalactic prison as a result of making prank phone calls using an intergalactic telephone, upon which they decide to cooperate in order to break out of prison.
An outing to the mall takes an unexpected turn as Uncle Grandpa and Pizza Steve end up stuck on a kaput escalator.
As Uncle Grandpa winds up in the North Pole, he tries to save Christmas by joining forces with Santa Claus to bring children their presents.
When Uncle Grandpa spoils Christmas dinner, the Guardian Lobster lets him see what his pals' lives would have been like if he weren't in them.
As Sandy's father turns down her request to get a dog, Uncle Grandpa decides to transform himself into a dog to help her learn to be responsible.
After Uncle Grandpa convinces Giant Realistic Flying Tiger to become friends with a mouse she found aboard the RV, the two new friends start trashing the RV, much to Uncle Grandpa's annoyance.
When Mr. Gus obtains Pizza Steve's diary by mistake, the latter attempts to retrieve it before his friend opens it and discovers the stuff he's hiding.
On his way to the city court, Uncle Grandpa drives the RV into a basketball court, where a group of players dare him to play a game against them, and if they win, they get his RV.
Uncle Grandpa and the gang exploit the generous Tiny Miracle's kindness, unaware that it might have a bad effect on his well-being.
In an attempt to help Tommy, the new kid at school, make new friends, Uncle Grandpa gives him a funky haircut that proves unsuitable for school.
As Pizza Steve prevents Uncle Grandpa from sleeping at night, frightening occurrences ensue.
Set in prehistoric times; a newly-hatched Mr.Gus seeks Uncle Grandpa's help as he tries to escape from some cavemen who want to eat him.
As Uncle Grandpa finds an unsettling message in a fortune cookie, he decides to investigate in order to learn which of his pals bears him ill will.
Uncle Grandpa fails to take out the garbage, which mounts up and forms a huge heap where his friends get lost, so he is forced to embark on a mission to rescue them.