Kara is a refugee from Krypton, Superman's cousin who arrived on Earth after he took on the superhero mantle. Kara reveals her powers to the world when she steps in to prevent a plane crash.
As Kara tries to find a way to improve perception of Supergirl, she finds herself embroiled in a chase that reveals more than she wanted to Astra.
When Kara accidentally reveals her connection to Superman, she finds herself the target of an old enemy of his. Kara confronts her feelings for James and what his ex-girlfriend's arrival means for them.
Cat Grant becomes the target of a disgruntled employee who gains powers after a freak accident. The arrival of Alex's mom reveals hidden secrets about her father and his connection to Hank Henshaw.
The two sides of Kara's identity clash as the threat she faces as Supergirl puts Cat Grant's son in danger, after Cat left him in Kara's care. Alex and Kara realize that Maxwell Lord is more dangerous than they thought.
Winn helps Alex and Kara get information about Jeremiah's death. General Sam Lane tries to get the measure of Supergirl's strength, only to end up in danger from a disgruntled former associate.
As an earthquake hits, Kara struggles to figure out a way to save everyone as her powers go out on her. Alex uncovers the truth about Henshaw and what happened on the night her father died.
Kara's confrontation with Astra reveals unexpected surprises about her own mother's actions and the reason Alura turned on Astra. Kara helps Cat Grant when a hacker leaks her personal secrets to the press.
As Non tries to use Hank to secure Astra's release, Kara faces a dilemma as she struggles to handle the situation at the DEO and refute Cat's belief that she is Supergirl.
When Winn's father, a convicted killer, breaks out and tries to force his son to participate in his criminal activities, Supergirl is forced to step in to help. Alex and Hank come up with a plan to learn more about Maxwell Lord, but he double-crosses them.
Hank's traumatic past come to light after an alien that wiped out his race carries out a kidnapping. Kara tries to mend bridges between Cat and her estranged son, Adam.
A lookalike of Supergirl appears in National City due to the machinations of Maxwell Lord, sending Alex on the defensive as she aims to stop Lord from hurting her family.
As Non concocts a plot to distract Kara, Astra goes behind his back to tip Alex off so that she could save her. A confrontation between Alex, Hank, and Astra ends on a tragic note, threatening to tear apart a strong relationship.
As Kara reels from Astra's death, she has to reevaluate how she feels about Hank/J'onn J'onzz. Kara investigates Myriad as she tries to stop the rampage of a Fort Rozz's guard who wants to kill all alien criminals.
Supergirl goes against Indigo, an alien that uses the internet to travel and who has a connection to Kara's past. As Kara races to save National City from destruction, she makes a decision about her affiliation with the DEO.
When Supergirl becomes compromised as the result of exposure to Red Kryptonite, she risks losing one of her most vocal supporters as her attitude takes a drastic turn. J'onn makes a sacrifice to help Supergirl return to herself.
As J'onn's real identity comes to light, Lucy gets involved in the investigation into how he impersonated Hank Henshaw. J'onn discovers a shocking revelation about Jeremiah.
Siobhan gains a deadly ally in her quest for revenge against Kara. Supergirl finds unexpected help when the Flash arrives from a parallel universe and quickly gets embroiled in the fight.
As Non puts his plans into effect, Kara struggles to find a way to counter his plans with most of humanity fallen under Non's control.
With Alex turned against Kara, the latter must find a way to break Non's control on her sister and the world at large. Things look bleak when Non and Indigo switch their plans into eradicating all of humanity.