Taking place in Victorian London, Ethan Chandler, Sir Malcolm Murray, Victor Frankenstein, and Vanessa Ives try to confront supernatural activities.
In season two, Ives is hunted by a group of witches led by Evelyn Poole, who wants to hand Ives over to Lucifer. Frankenstein is forced to make a bride for his creature, and an inspector investigates a horrific murder committed by Chandler in a London inn.
In season 3, Ethan Chandler, Sir Malcolm Murray, Victor Frankenstein, and Vanessa are scattered throughout the world, each fighting their own demon.