An unlikely friendship forms between old respectable detective Roger Murtaugh and his new partner Martin Riggs, an unstable detective whose family was just murdered.
In Season 2, Riggs plots to eliminate Tito Flores in Mexico with Murtaugh following him, Riggs and Murtaugh uncover a drug ring at a health clinic while investigating the death of a plastic surgeon, and Riggs and Murtaugh investigate the death of a famous singer's bodyguard.
Former CIA operative Wesley Cole returns home and partners with Murtaugh. Avery runs for City Council. Cole and Murtaugh try to balance their family life with their mission to arrest a gang running a lottery scam.