Seeking a fresh start, junior doctor Ruby Walker decides to leave her comfortable life in England and travels to Good Karma hospital in India, where she's overwhelmed by its limited resources and the number of patients. Ruby manages to prove her skills when she handles a difficult pregnancy.
When an amnesic man washes ashore, he's taken to Good Karma hospital where Dr. Lydia uncovers his identity and helps him deal with his condition. As Ruby helps children in a village, she gets to know the pupil Vijay.
After Dr. Fonesca manages to reunite a father and son, her diagnosis leads them to drift apart. When an infant's life becomes at risk, the officials are left to consider their options. AJ realizes that lying about being a doctor could jeopardize the lives of innocent people.
Things take an unexpected turn when Ram clashes with Lydia during a fancy Indian wedding when a medical case turns into a personal conflict.
As Lydia and Ruby make a miraculous diagnosis when they go to a convent, it leads to tension between them. Maggie and Paul go for a walk in the woods to join a group of pilgrims.
With the monsoon season approaching, tension mounts between Lydia and Ruby, which drives Ruby to make a surprising decision. As Maggie's health continues to go downhill, she's determined not to leave India.