In the wake of a tragic bombing, Mulder and Scully are on the outs with the FBI. But as a mysterious substance with alien origins starts infecting people, the two partners uncover a conspiracy that links the bombing to the potential spread of the alien virus.
It is former FBI agent Fox Muler's time to retire, but another agent disappears as predicted by a claimed psychic. The FBI then asks former agent Dana Scully to convince Fox to help them find the missing agent.