When Donald Duck loses his boathouse, he's forced to go to his estranged uncle Scrooge McDuck, as he takes his nephews, Huey, Dewey, and Louie, with him. As the triplets join Scrooge in an adventure to find the Lost Jewel of Atlantis, they end up staying with him in his McDuck Manor.
When the triplets take the housekeeper's granddaughter Webby to Funso's Fun Zone, things go south when the Beagle Boys kidnap them to ask for ransom from Scrooge. Donald and Mrs. Beakley are not getting along.
When Scrooge notices how lazy Louie is, he decides to show him his Number One Dime, but things get out of control when Louie ends up losing it. Webby accompanies Dewey in order to find information about his missing mother, Della.
As Webby befriends the rebellious teen Lena, they land in trouble when they crash Ma Beagle's birthday party. As the boys look for them, they try to escape from the Beagle clan.
As the boys set out to discover if the legendary creatures the Terra-firmians are real, they end up trapped in an abandoned subway, while the chauffeur Launchpad starts to suspect that Louie is hiding a dark secret.
On the way to one of their adventures, the Scrooge family take a quick stop at a casino resort in Macaw, where Donald ends up competing with his lucky cousin Gladstone Gander, while Scrooge and the boys try to find a way to get out of the casino.
As Huey and Dewey look forward to getting an internship with the tech mogul Mark Beaks, things get out of control when the industrial spy Falcon Graves sets out to get rid of him. Scrooge joins forces with his archenemy Flintheart Glomgold to stop Beaks.
As Scrooge and the boys embark on an adventure to find the lost tomb of the pharaoh Toth-Ra, things take a turn when they get captured by Toth-Ra himself, as they try to find a way to escape.
Scrooge takes the boys on an exciting adventure, as he sets out to achieve his old dream of climbing Mount Neverest, while a salesman tries to trick Launchpad.
When the Scrooge family finds themselves on the Greek Island of Ithaquack, Dewey tries to uncover the mystery behind Della's disappearance, while Donald is forced to compete with the son of Zeus, Storkules.
Launchpad finds himself at risk of losing his job when Beaks invents a new, self-driving car. But when the inventor Gyro and the intern Fenton discover Beaks' evil plans, Launchpad gets his chance to prove that he can't be replaced with a robot.
As Scrooge competes with Glomgold in a game of golf, things get out of control when they get trapped, as they have to escape from a dangerous place and scary creatures.
As Scrooge's birthday arrives, Huey sets out to throw him a great party. But his plan backfires when Scrooge ends up missing and the ghost of his late butler Duckworth could be behind it.
Driven by orders of the evil sorceress Magica De Spell, Lena sets free a giant money shark that terrorizes the city of Duckburg. Meanwhile, Scrooge tries to improve his public image.
As Scrooge sets out to find a lost treasure, he joins forces with his scheming old love Goldie O' Gilt, but their search is disrupted by the arrival of Glomgold who wants to have the gold to himself.
As Dewey invents a holiday that allows each of the triplets to spend a day by themselves, each one of them does his favorite activity, only for them to realize that they're better together.
When Mrs. Beakley is kidnaped by an old enemy, Scrooge and Webby set out to save her, as the story of how Scrooge and Mrs. Beakley first met is revealed.
When Fenton suits up as the robotic superhero Gizmoduck to save Huey's life, Mark Beaks offers him a job. But when Beaks' evil intentions are revealed, it's up to Fenton to step up and keep the city safe.
As Magica is desperate to put her hands on Scrooge's Number One Dime, she makes her niece Lena help her find it. As Lena becomes torn between her loyalty to Magica and her friendship with Webby.
After a band of pirates led by Don Karnage loots Scrooge's treasure, Dewey decides to join the pirates when he feels left out. But Dewey has a change of heart as he joins his family to retrieve the treasure.
As Scrooge sets out to find a new treasure, he has a meeting with his parents as he patches things up with his father. As Dewey has trouble hiding the truth about his mother from his brothers, they eventually team up to help him find her.
When their plane crashes onto a mountain peak, Scrooge and the rest of the family find themselves in danger, while the kids try to find clues that lead them to Della. But when Scrooge reveals the mystery behind Della's disappearance, everyone walks away from him.
As Scrooge is left all alone, Magica sets out to execute her evil plan to take over Duckburg by possessing Lena's body. As Donald and the boys join forces with the rest of their friends to face Magica, Lena makes the ultimate sacrifice to save everyone.