Dr. Dylan Reinhart has left his life in the CIA behind for a career as an author and a professor. But when homicide detective Lizzie Needham comes to him with a case that is connected to one of his own books, he finds himself back in a world that he thought he left behind.
Lizzie is back with a new case for Dylan that involves a ritualistic display of a murder victim. Dylan faces the question of whether he should partner up with Lizzie permanently.
As Lizzie and Dylan try to solve the murder of an aspiring pianist who walked out on his religious community, Lizzie is forced to balance the case with her family issues as her sister Katie shows up in town.
With Dylan's father in town to investigate a chemical attack, Dylan falls into old patterns of trying to prove himself to his estranged father, which is made more complicated by his theory that the chemical attack is connected to a murder in Central Park.
A gruesome murder leads Lizzie and Dylan to go on the hunt for a stalker after they discover that he killed the wrong woman. But their investigation reveals more than they bargained for.
After one of their arrests inexplicably dies after stabilizing at the hospital, Lizzie and Dylan follow the trail of a number of mysterious deaths. But are those the result of medical negligence or do they have an angel of death on their hands?
When Jasmine's friend dies in an apparent accident, Dylan casts doubt on the circumstances of her death, leaving him and Lizzie to investigate the murder after a 911 call confirms his suspicions.
With a media frenzy erupting over the shooting of a Muslim woman in plain sight, Dylan and Lizzie face tremendous pressure from the mayor to solve the case within 24 hours.
The murder of two members of an acting troupe leaves Lizzie and Dylan looking for a sophisticated killer capable of using unconventional methods to get to his victims.
Lizzie struggles to ask for help when she confronts some concerning facts about her late fiancé's last operation, which could be connected to his murder.
When several innocuous people are inexplicably turned into suicide bombers, Dylan and Lizzie struggle to figure out how they are connected or why they have blown themselves up.
When the grisly murder of a film student is made into a spectacle and broadcast to the world, Dylan and Lizzie's investigation leads to a big pool of suspects, all with the talent and ability to film such a video.
Dylan and Andy make a big personal decision. One of Lizzie's past actions comes back to haunt her. Secrets come to the surface as Dylan and Lizzie look into the murder of Joan's protégé.