When Spike is sent to obedience school, Jerry finds himself defenseless as Tom continues to go after Jerry. Tom lands himself in trouble after he causes a mess with a magic wand, as he tries to fix the situation before the witch sisters, Hildie and Beatie, find out.
As Ginger has trouble sleeping, she buys a new mattress and warns Tom not to come near it. When Tom and Jerry go camping, Tom gets upset for not having fun like Jerry, only for him to land in trouble with a bear.
As Tyke's birthday arrives, Spike makes Tom and Jerry be in charge of the party. When Toodles enlists the help of Tom and Jerry to protect her Tuna can, they find themselves facing a scary threat.
As Tom and Jerry fight over the cover, they find themselves locked out of the house. After using up eight of his nine lives, Tom uses a magic spell to bring back his duplicates.
Tom lands himself in trouble after falling into a trap he made for Jerry. Polly the Dog enlists the help of Tom and Jerry to retrieve her collar from Barkley who falls for Polly.
When Jerry helps Little Quacker fix his birdbath, they have trouble focusing, as they get tempted when they smell Tom's tasty food. When Spike uses Tom and Jerry's help to build a swimming pool for Tyke, he soon regrets his decision.
When Ginger looks after her mother's bird, Jerry tries his best to keep Tom and Butch from eating the bird. As Jerry pulls a prank on Tom by pretending to be a vampire, Tom attempts to face the scary vampire mouse.
When Rick goes away, Spike steps in to keep the house safe from burglars, while teaching Tom and Jerry to be prepared. When Dr. Bigby mistakes Tom for his mean cat Wilson, Tom must find a way to fix this mix-up.
Butch pulls a prank on Tom by switching places with him, as Tom gets to experience how it feels to be a street cat. When Tuffy starts to think that his house is haunted, he enlists the help of Tom and Jerry to uncover the mystery.
When Spike has allergies, Rick suspects that Tom caused it, so he brings Ginger a new kitten named Glory. As Spike, Tom, and Jerry team up to get rid of her. When Dr. Bigby comes up with cookies that give superpowers, Jerry and Napoleon eat them and scare Tom.
In the aftermath of a messy chase, Rick takes Tom and Spike to be checked by the vet, while Ginger calls the exterminator to get rid of Jerry and Tuffy. When Hildie and Beatie send Tom and Jerry to bring an important ingredient, things don't go according to plan after Tom falls for Princess Toodles.
When Tom throws Spike's chew toy out, he regrets what he did and sets out to bring it back. Tom and Jerry have to prove their detective skills after Butch and a squirrel steal their clients and jeopardize their business.
When Tom and Jerry have the house to themselves, they compete with each other as they invite their girlfriends to dinner. When Dr. Bigby uses Jerry in one of his experiments, Tom takes advantage of Jerry's new lovable nature.
As Butch tries to keep Tom from going out on a date with Toodles, Jerry and Tuffy think that there is a monster in the basement. When Tom and Jerry accidentally ruin a Christmas tree, they set out to fix the situation while helping Santa save Christmas.
As Jerry and Tuffy plan to go on a vacation, Tuffy ends up being left behind, as he shows Tom that he's not to be messed with. A clumsy magician enlists the help of Tom and Jerry to find his missing pigeon after it vanished away during a magic act.
Tom and Butch face a tough challenge as they compete to prove who's the best cat by attempting to catch Jerry. As Hildie and Beatie honor the memory of their mother who passed away, Tom attempts to bring her back to life.
As Tom is asked to be in a documentary, they follow him around the house to record his daily activities. But they misinterpret everything he does. When Dr. Bigby creates a transporting machine, Tom and Jerry find themselves in Paris where they meet two new faces.
As Ginger and Rick take Tom and Spike with them on their Hawaiian vacation, things spiral out of control when Jerry and Tuffy decide to come along for the ride. Jerry and Tuffy continue to wreak havoc after Ginger and Rick sneak Tom and Spike into their resort.
When Rick and Ginger go on a cruise ship, they hide Tom and Spike in the carriers, only for Jerry and Tuffy to cause further chaos. When Tom and Spike get lost during a road trip with Rick and Ginger, they run into an unexpected hurdle.
When Hildie and Beatie bring a magic mirror that predicts the future, Tom sees something that disturbs him, as he sets out to keep it from happening. When Spike's bones go missing, he asks detectives Tom and Jerry to help him find them.
As Dr. Bigby upgrades his robot, things go south when Tom accidentally causes the robot to be out of control. When pests destroy the garden of the witch sisters, Tom tries to help them, but things don't go as planned when Little Quacker gets caught in the middle.
Tom and Jerry get in over their heads when they accidentally drop Ginger's wedding ring down the drain, as they attempt to get it back against all odds. After Dr. Bigby invents a helmet that turns its user into a genius, Tom puts it on as he figures out a smart way to catch mice.
When Tom thinks that the cat Misty is in danger, he and Jerry enlist the help of the dog Scarf to find her. When the witch sisters decide to replace Tom with a black cat, he sets out to stop them by taking extreme measures.
As Tom, Jerry, and the rest of the pets freak out during a snowstorm, they set out to bring as much food as they can in case they run out of food. When Jerry and Napoleon try on Dr. Bigby's anti-gravity machine, Tom decides to join them, as a wild chase ensues.
As the witch sisters take a vacation, Tom and Jerry face a hurdle when their ghost nephew, Grayson, shows up and invites his friends to a big party. Tom and Jerry face an unlikely challenge when they have to figure out a way to save Earth from an asteroid that's heading towards their planet.
Detectives Tom and Jerry are called upon to help the hapless dog Dutch retrieve his grandpa's precious ruby stone. Tom has an unusual day as he sees hallucinations after he tries out a new cheese that Rick and Ginger bought.