The return of Owen's sister, Megan, leaves Meredith caught up in an uncomfortable situation, especially as she becomes Megan's doctor. Arizona's one-night-stand turns out to be connected to one of her colleagues.
Carina pitches a controversial study to Bailey. Meredith tries to navigate the awkward situation with Megan as she comes up with a daring surgery to help treat her. Amelia makes a shocking discovery.
As Amelia spirals in the wake of her diagnosis, Richard steps in to assure her about the validity of her medical decisions. Bailey clashes with Jackson's grandfather, renowned surgeon Dr. Harper Avery.
Meredith and Nathan are forced to work around the law to reunite Megan with her adopted son. Owen and Amelia confront the impact of her brain tumor on their relationship. Jo admits to still not being over an old trauma.
As the Hunt siblings go on a trip, they reflect on the circumstances that led to Megan's fateful flight that ended with her abduction.
Amelia struggles to get back in the saddle after her brain surgery. Jackson makes a decision about his inheritance. Jo takes measures to sever all ties with her traumatic past and look forward to a brighter future. Jackson goes on a relaxing trip at sea with the guys.
An influx of patients reminds the doctors of Grey Sloan of familiar faces, forcing them to reflect on old memories and relationships. Bailey pushes back against Ben's new career decision. Meredith achieves a professional victory.
With the hospital's computer system held for ransom, the doctors are forced to come up with alternative ways to treat their patients without the help of technology. A face from Jo's past arrives at the hospital.
Forced to confront her abusive husband, Jo must find a way to navigate her workplace as trauma threatens to pull her under. Bailey receives help from an unexpected source as she tries to gain back control over the computer system.
As Jo tries to reach out to Paul's fiancée, a sudden mishap proves to be Jo's salvation from unresolved trauma. A case involving racial profiling hits too close to home for Bailey and Ben. April confronts her past.
Bailey's life hangs on the line as she recognizes the symptoms of an impending health crisis, forcing her to reflect on how she got to where she is.
With the medical innovation competition heating up, Meredith receives inspiration from an unlikely source. April finds herself as the judge of which medical research will receive funding.
As a house fire brings the firefighters of the Seattle fire department to Grey Sloan, Ben struggles to adjust to the difference between his new job and his old job as a surgeon. Amelia receives help from her old mentor as she attempts to help a patient.
Meredith takes a risk while meeting an old acquaintance of her mother's in order to secure a patent for her research. April's downward spiral starts to affect her career.
Meredith faces a difficult choice between the needs of her own research and the need to preserve her mother's legacy. Jo makes a daring move in her relationship with Alex.
Richard and Catherine try to adjust to the news of Jackson and Maggie's relationship. Jo steps in to prevent Meredith from giving up on her research. Bailey meets one of her childhood heroes.
A patient helps April find solace in her crisis of faith. Teddy challenges Owen's relationship decisions after he attempts to get together with her.
Meredith and Jo catch a break in their medical research. April tries to put her life back on track. Arizona and Owen join forces to investigate a shady oncologist, leading to unexpected results.
With one of the interns facing deportation, Bailey, Meredith, and Andrew join forces to try and protect her. Jackson makes a decision that has unexpected results on the Harper Avery foundation.
As the hospital prepares for the final stage of the medical innovation contest, most of the doctors end up accidentally drugged after a patent brings in cookies laced with cannabis. Jackson learns of the dark history attached to the Avery name.
As the Averys deals with a PR nightmare after the news of Harper Avery's sexual harassment goes public, Meredith and Jackson team up to find a way to rehabilitate the foundation's image. Owen and Amelia make steps in their role as foster parents.
Alex and Jo try to figure out if the latter's mother is alright. Meredith makes a decision regarding Marie Cerone. Amelia struggles with her own sobriety as she tries to help Betty beat her addiction.
A familiar face inspires Arizona to seek another path for her future. As the life of one of their own hangs on the line, the doctors race against the clock to figure out a treatment.
As Arizona starts a new chapter of her life, Teddy arrives in Seattle with unexpected news. Alex and Jo's wedding day is beset by various complications, sending various doctors scattering to save lives.