After her boyfriend leaves her, Jules Wiley discovers that she has had no female friends for 5 years, She tries to win her female friends back.
Jules asks her friends for advice about leaving her ex's place, but can't decide to take which friend's advice.
Jules faces a hard time as she tries to figure out how to keep secrets between friends.
The girls struggle with labeling each other with names: Jules the "boring one", Stella the "fun one", Madison the "bossy one" and Izzy "the crazy one".
Jules goes to her ex-boyfriend's sister's bachelorette party and pretends that she is over him. Madison tries to impress her older boyfriend.
The girls are scared of a possible major earthquake hitting Los Angeles and Jules is worried about bumping into her ex-boyfriend with a new girl.
The girls explore an unfamiliar world of dating and sex.
Jules discovers disturbing news that will affect Madison's relationship and the future of their friendship.
The girls explore the feminists' world during a Women's March.
In the wake of the recent events between Madison and Jules, the four girls go to Mexico for a wedding weekend, where everything goes wrong.