Interior designer Grace moves in with her gay best friend Will after a broken engagement. What starts as a temporary arrangement turns into a permanent life situation.
After Will takes over as tenant board president, Grace feels that he is abusing his power, so she decides to run in the elections against him, then Grace's picture is published in a newspaper, which gets her into an unexpected mishap.
Season three begins with Will's return from the Caribbean, only to discover that Grace has fallen into a complicated love triangle, and that Jack has taken his place as Grace's best friend, beginning a new and complicated chapter in the friends' lives.
Will returns from his vacation, which angers Nathan because of his romance with Grace, then a bully from Will's past returns to join the law firm where he works, turning his life upside down.
In season 5, the lawyer Will gets into big trouble when a tough new boss arrives and orders Will to fire his friend in the firm, and then many events follow.
A dinner party hosted by Grace with the help of Leo brings unpleasant surprises, while Will continues to look after his mother before he convinces his client, Karen, to undergo a medical examination, but she ends up in a difficult situation.
After breaking up with Leo, Grace tries to overcome her sadness before suddenly meeting with an old friend and putting herself in trouble after everyone discovers she is a fraud.
The controversial events in Grace's life escalate when she tries to explain to Tom her refusal to pursue a relationship with a married man, but he insists on pursuing her, while Will gets involved in many problems with Karen.
Will and Grace are back to living in the same apartment and dealing with a whole new slew of challenges, from differing political stances to dealing with the fact that they are not as young as they used to be.
Will and Grace reside in a New York City apartment. She is an interior designer, and he is a gay lawyer. Karen, an affluent and attractive socialite, and Jack, a happy but proud gay man, are their best friends.
Grace begins a new chapter in her life after returning from her travels, but everything quickly takes a turn when she receives unexpected family news.