The events revolve around the lives of a group of teenagers on the East Side of New York, including Serena van der Woodsen, Blair Waldorf, and Nate Archibald, and the many strange events and actions that the trio witnesses in their lives.
As Blair plans her wedding, she has to reckon with her feelings for Chuck, which brings about unforeseen tragic consequences. Meanwhile, Serena tries to prove herself on the movie set and decide on the direction she wants her life to take.