The Powerpuff Girls must find out how to save Donny the Unicorn while he is being pursued by an opponent who appears to be unstoppable.
When Buttercup volunteers at a nursing home, she encounters an elderly woman who claims to have once been a superheroine named Green Wing.
As a well-known director, Bubbles tries her hardest to maintain the popularity of her video after it goes viral.
After each of them fights independently, the Powerpuff Girls come to respect one another's fighting technique.
Buttercup makes a promise to catch a fabled uncatchable crawdad while at the lake.
Blossom wants to keep Buttercup, Bubbles, and the Professor at home so they won't attend Princess Morbucks' sixth birthday celebration since she is the only one who wasn't invited.
Blossom believes she will be given the leading role in the school play; however, it turns out that Bubbles is selected to play the lead, so Blossom attempts to screw up the situation.
Despite frightening forebodings of terrible consequences, Buttercup takes her mini-golf ball victory too seriously.
The Powerpuff Girls are finally challenged to a volleyball match, which they must win to rescue the beach, by a group of sharks known as the Bro Sharks who have just arrived.
Blossom and Buttercup attempt to keep the Professor from finding out that Schedulebot was broken and buried, while Bubbles looks into the matter.
When the girls first encounter the Absman, he makes them feel bad about themselves because they aren't as bulked up as he is, so Buttercup decides to visit a gym and build muscles.
While spending the day with the Professor in his dull office, the Powerpuff Girls discover that the space has a dreadful secret.
Bubbles decides to work as a dog sitter to demonstrate that she is trustworthy enough to own a dog. Before long, Bubbles intervenes as Paulie the dog stops to rob a jewelry store, only to have the dog inform her that she is now his accomplice.
Buttercup strives to avoid being referred to as a nerd as she tests in Honours Maths.
Blossom struggles to see the educational benefit of the amusement park rides and funfair games when the girls visit Camp Big Dipper, but she quickly learns that having fun and spending time with friends are equally vital.
Bubbles begins to wonder if she has ever been a hero while looking through the Professor's scrapbook.
A monster starts disrupting the vacation of the girls and the professor at the Abundant Aranita Resort, and the girls quickly get attacked by spiders and run into Sapna, the Professor's old flame.
At school, Bubbles' wild imagination leads to a minor catastrophe as Him transforms the school into a terrible scene and uses Bubbles' conductor to rob her of color and joy.
Buttercup is compelled to work with Jared to save her sisters after becoming trapped in his preferred board game.
On the day the girls go to the dentist to get their teeth cleaned, Blossom develops a toothache and is so terrified of having the dentist drill into her that she misses the appointment and becomes increasingly monstrous as the swelling grows.
The Powerpuff Girls are compelled to take Mojo in after his most recent creation puts him in danger of being blasted into tiny pieces.
Blossom is reluctant to attempt again after making a poor decision. Meanwhile, Bianca refuses to acknowledge the love that develops between Mojo and Barbarus.
The Powerpuff Girls begin to believe Mojo and Barbarus are doing something wrong when they announce their engagement and marriage.
The girls discover they have a sister named Bliss. / The girls discover Bliss's past. / The girls hang out with Bliss, who gets a taste of bad-guy combat. / When Bliss fights to control her powers, an evil force emerges to exploit her. / When Bliss' powers are absorbed, the girls must save her.
When a dangerous creature stalks the Mayor's residence, the Powerpuff Girls must intervene.
When Bubbles feels overworked, she turns to her coding knowledge to provide a fresh approach.
When Mojo steals the karaoke machine from a puppy orphanage on Christmas, he causes a stir. However, when he gets home, he passes out and dreams that Blossom, Bubbles, and Buttercup are visiting him in a dream.
Before the big dance, the Powerpuff Girls and Bliss must figure out how to put an end to the parasitic alien that has taken over their school.
Buttercup lengthens her hair to get a mullet, but she contracts Super Lice as a result. The Professor shrinks Blossom and Bubbles to get rid of the lice as a defense mechanism.
Jemmica pleads for assistance in locating an object known as the Cube of Doom. Blossom and Bubbles decline after thinking back to their previous interaction with her. But despite Blossom's misgivings, Buttercup offers to help.
To thwart the Gnat's most recent nefarious scheme, the Powerpuff Girls must get through their turbo difficulties.
When Mojo takes the Powerpuff Girls' favorite cuddle toys hostage, he ends up with more than he anticipated.
Bubbles offers to take the place of one of the injured Derbytantes after she sustains an injury while playing Deathball. Bubbles initially feels uneasy, but she eventually gets used to playing for the team. However, Buttercup feels jealous.
Blossom and Buttercup are perplexed when Bubbles sinks into a blue depression. To their chagrin, no matter what they do to cheer her up, it doesn't succeed.
The Utoniums are forced to reevaluate their superhuman lifestyle by a refined queen of manners.
After being hit by Man Boy's beard ray, Bubbles causes mayhem in the most charming and macho manner possible.
Blossom's doubt is put to the test when she thinks she's met an alien from outer space.
The reality show Aliver takes place to determine the best superhero in the world, and Princess Morbucks competes just like the girls.