When Covid-19 pandemic hits, Meredith Grey and the surgeons of Grey Sloan Memorial are fighting for their patients' lives.
While Winston and Maggie's relationship goes to another level, Owen and Teddy break up. Meanwhile, Meredith faints in the parking lot and has a vision where she sees Derek Shepherd.
Meredith is hospitalized with a positive COVID-19 diagnosis, and her condition continues to deteriorate. Meantime, Amelia and Maggie look for consolation while struggling with what is happening to Meredith.
While Tom is forced to remain quarantined after testing positive for the second time, Owen faces a previous patient, he treated before, that is now admitted with a worsened condition Maggie finds herself in an awkward situation with Winston's father.
When an assisted living home is hit with a COVID, Bailey worries when she sees a familiar face among the patients admitted. Koracick is admitted to the hospital with COVID as his condition is rapidly deteriorating.
As Meredith's condition starts to improve, it doesn't stay for long when she tries helping a coding patient. Richard turns the cafeteria into a COVID-19 treatment room and activates surge protocol.
After Andrew is stabbed, the hospital staff try to save his life. Meanwhile, Amelia and Link discuss an important decision to make regarding Meredith's health.
When stress and tensions arise, each of the Grey Sloan doctors has his own way to get through what is happening. Meanwhile, Hayes urges Meredith to fight for her life.
As Teddy might be having PTDS after Andrew's death, Amelia tries to help by convincing Owen to forgive her infidelity.
While Maggie and Jackson have a tough call to make regarding the last ventilator in the hospital, Meredith is still in her vision at the beach with Mark Sloan and Lexie Grey. Winston pops the question to Maggie.
Jackson clashes with Mama Ortiz over his magnanimity to COVID patients. Meanwhile, Meredith wakes up and tells Richard about overhearing Jo's consideration.
Bailey and the team struggle to treat a man tested positive, but believes that the pandemic is a scam. Meantime, Winston moves in with Maggie after their engagement.
After Teddy, Richard, and Winston look for ideas to help Meredith wake up, they get an idea on who might help in that matter. Meanwhile, Jo tries to persuade Bailey to let her switch specialties as Teddy tries to reconcile with Owen but fails.
Jackson has a proposal to April Kepner after seeking advice from his father.
Jackson says his goodbyes after announcing his news. Meanwhile, Richard and Bailey are trying to figure out how to tell Meredith about Andrew's death. Amelia struggles to get the house ready for Meredith when she is discharged from the hospital.
While Meredith begins her recovery process, she is concerned about her future in the operating room. Meanwhile, Jo hopes to adopt baby Luna and Schmitt is accepted in COVID-19 vaccine trial.
Meredith is the Director of the Residency Program and while Jo is determined to adopt Luna, she makes life changing decisions. Maggie and Winston finally get married.