In the second season, all the animals are faced with many existential questions, while New York City is experiencing a mysterious virus outbreak that plagues its streets.
Phil Jr. and Mike find themselves losing their minds, as they begin to believe that they are in a love triangle with an imaginary friend, after being abducted as lab rats. After being stuck on a monkey's back, two fleas contemplate life, while an algae wonders about its purpose in life.