After getting fired from their work as parapsychologists at Columbia University, the trio Peter, Raymond, and Egon start their own private business to fight the paranormal activities in New York City.
Years after they successfully saved New York, the Ghostbusters have fallen on hard times and shut down their business. But when Dana calls them to save her child from an evil spirit, the gang comes back together to save Dana's son and the residents of New York.
Paranormal enthusiast Abby Yates and physicist Erin Gilbert form an unlikely paranormal investigating team with engineer Jillian Holtzmann and subway worker Patty Tolan. As ghouls descend on Times Square, the four women uncover a plot to cause an apocalypse by summoning ghosts to New York City.
Upon their arrival in a small town, a family that consists of a single mother and her two kids finds out that they're somehow connected to the original Ghostbusters, and to their grandfather's legacy.
Ghostbusters from both eras must work together to defend their home and prevent a second ice age when an evil force is unleashed by the discovery of a long-ago artifact.