The series revolves around Detective Jane Rizzoli and Chief Medical Examiner Maura Isles, who form a team to solve and uncover crimes that occur in Boston, Massachusetts.
Jane Rizzoli is honored for her efforts and dedication to her work, and she soon becomes involved again in solving crimes with her friend Maura Isles and the rest of the team.
Jane Rizzoli and Maura Isles continue their work to solve and uncover crimes, while Maura discovers a mysterious secret about her real mother. She faces several difficulties in her professional and family circles, but Jane always stands by her side.
Together, Chief Medical Examiner Dr. Maura Isles and Detective Jane Rizzoli investigate murders in Boston.
Detective Barry Frost dies, pregnant Jane continues to work despite being exposed to many dangers, Maura continues to struggle with her love life, and crime scene and IT analyst Nina Holiday joins the team.
Jane and Maura continue to work with their team to solve serious cases in Boston. Maura faces dismissal from her job due to a crime, but Jane seeks to solve the case and help her return to work, as secrets in both of their lives are revealed.
In season seven, the Boston Police Department seeks to arrest Alice Sands and bring her to justice before she destroys the life of Jane, who continues to solve mysterious crimes with Maura.