Organized crime clans fight wars and make fleeting alliances in the underworld of the impoverished Italian city of Naples. Gomorrah, son and heir of the Savastano clan, and Ciro di Marzio, one of the officers of this clan, have a great ambition to advance to ever greater heights.
Ciro puts his life and the lives of his entire family at risk in his attempt to become the next boss of his own gang. With Don Pietro gone, Ciro begins building a new drug empire with Salvatore Conte.
Genny takes control of the cities of Naples and Rome and includes them within his network, while Ciro forms a new partnership with Enzo, resulting in signs of a peace agreement with Genny under specific conditions.
After Ciro's death, Naples becomes in a state of chaos, and Genny resorts to searching for a partner to support him while trying to expand his business circle and launder his money to hide its suspicious sources.
The feud between the Levante family and Patrizia escalates, and then the city of Naples descends into chaos, which prompts Genny to abandon his dream of a normal, quiet life and go back to work.