Larry is newly recruited as a night security guard at the Museum of Natural History, he discovers that an ancient curse brings all the creatures at the museum to life by night.
Larry Daley, now a successful businessman, is drawn to the Smithsonian Institution after his friends are shipped there. With the Tablet of Ahkmenrah bringing all the Smithsonian's exhibits to life, it's up to Larry to protect the tablet from a group of evil historical figures.
When the magic powers of The Tablet of Ahkmenrah begin to die out, Larry Daley (Ben Stiller) goes on a journey around the globe, uniting his favorite and new characters while embarking on an epic quest to save the magic before it is gone forever.