Raymond "Red" Reddington, an ex-government agent and an FBI Most Wanted fugitive suddenly turns himself in to the FBI, and offers to reveal everyone he worked with, including a terrorist believed to be dead, but only on one condition.
Red predicts an impending disaster caused by the work of "The Freelancer", a famous assassin.
Liz goes with Red on a secret mission to bring down a freelance Chinese spy who is going after CIA agents.
After the disappearance of a witness in the murder trial of a merciless cartel boss, Red, Liz and Ressler embark on a search for the Blacklist's no. 161.
Liz discovers evidence which links Tom to the unsolved murder of a Russian defector.
After confronting Liz about the box, Tom claims to be innocent and is insistent they turn it in to the FBI so that he can clear his name.
Red takes Liz on a journey to search for a lunatic chemical weapon specialist who has unleashed a deadly disease.
Red agrees to stop an anti-capitalist terrorist network's upcoming deadly attack on the condition of making a deal with Cooper.
There is an attack on the team's headquarters in an attempt to kill Red.
Terrorist Anslo Garrick kidnaps Red, and the responsibility of finding him falls on Elizabeth.
A serial killer from Liz's past reappears, while Red is going after his traitor.
Red seeks the help of activist whistleblowers to search for the mole, while Liz is on the hunt for a mad scientist who has helped many criminals escape.
Liz is the head of an investigation that reveals the shocking secret of an adoption agency. Meanwhile, Red's journey to pursue the FBI mole reveals a surprising suspect.
Liz helps Tom adapt to the upcoming adoption.
Liz and Ressler track down a criminal called The Judge, who imprisons those who destroy the lives of innocent men.
Tom battles to keep his secret hidden, while Ressler goes after Mako Tanida, a man who's targeting his old team.
Liz looks into the disappearance of Jolene while the team are tracking down a young man impersonating a notorious hacker named Ivan.
As Liz now realizes that Tom is not who he pretends to be, she sets out to uncover his real motives.
Red discovers that the Pavlovich brothers, who specialize in abductions of high value targets, are planning their next mission.
When a politician in Prague is framed for murder, Red is suspicious that The Kingmaker is behind it.
After finding out the truth about her father's death, Liz doesn't want to work with Red. However, Red presents the FBI with a case they can't turn down.
After the crash of the mysterious prisoner transport plane, the city goes on lockdown, as the authorities track down all the fugitives.