Being a part of the A.N.T. (Advanced Natural Talents) program, Chyna, Olive, and Fletcher are determined to attend the trendiest school party to show they are cool, even though they are young.
As the A.N.T. squad try to fit in with older kids, they join after-school activities, but things go sideways for each of them.
With Olive's locker being next to his, Cameron invents a story about her locker to force her to move. Elsewhere, Fletcher finds it difficult to make Principal Skidmore look pretty in a portrait.
Chyna suspects that school is treating A.N.T. members differently when she gets top grades in a test she didn't study for. Elsewhere, Cameron and Lexi keep the principal's phone after finding it so they can get a reward.
When Chyna finds out that Olive tricked her into running for student council, she tries to get back at her. Meanwhile, Fletcher tries to be friends with Darryl.
Fletcher's attempts to get closer to Chyna are ruined as she feels sorry for Gibson because of his grandmother moving out.
Darryl sends an undercover police officer when he accuses Chyna of shoplifting. When Chyna, Fletcher, and Olive find out about the officer spying on them, they pretend to rob a house.
Fletcher tires to ruin Chyna's date with the new A.N.T. member from United kingdom.
Chyna and Olive try to help Cameron find his talent when Principal Skidmore gives everyone in school an award for their talent except him.
When Hippo, a music producer, sees a video of Chyna singing and asks to make a music video for her and change her image, Cameron acts as her manager and refuses his offer.
When Principal Skidmore cuts down the school budget, the A.N.T. gang tries to raise money to get Gibson back after he got fired.
When Fletcher meets his favorite artist, Zanko, who is having an inspiration problem, the latter takes advantage of Fletcher as he tries to help him.
After the history teacher suffers a breakdown when Chyna forgets her homework again, Olive becomes the new substitute teacher for the class.
It's the Halloween dance party, and it's Chyna's first day in the "MUTANT Program", in which A.N.T.s are mutants and the older kids are humans.
Olive, Fletcher, and Angus help Chyna retrieve Madame Goo Goo's phone number after she loses it during a fortune cookie factory visit.
After Olive loses her memory from a loud noise caused by Fletcher, the team tries to help her regain her memory before Principal Skidmore excludes her from the A.N.T. program.
When Lexi decides to host a slumber party and doesn't invite Chyna, the latter decides to host one of her own and invite all the girls in the A.N.T program.
Chyna and Lexi get chosen to be the finalists in the reality show "America Needs Talent". Meanwhile, Olive and Paisley join a game show.
Chyna, Olive, and Fletcher are asked to make toys to give to an orphanage for Christmas, but instead, they find that they are for sale. As they try to ruin the toys before they are sold, Principal Skidmore changes her mind about selling them.
When Chyna gets the leading role in the school play "Grease", Lexi and Fletcher join forces to sabotage the show. Meanwhile, Cameron offers Gibson to live in his house after discovering that he has been living at school.
Chyna, Olive, Fletcher, and Angus decide to deceive Chyna's mom into letting Chyna go to a concert by a kid's band, while they really want to go to a horror punk band's concert.
Fletcher is forced to pretend that he has a girlfriend after asking Chyna out and her refusing by pretending that she has a boyfriend. Meanwhile, Gibson volunteers to coach the cheerleading team.
After Olive and Fletcher see a business opportunity, but they do not want to mix friendship with business, so they decide not to include Chyna. Elsewhere, Lexi gets jealous of Paisley getting all the attention.
When Violet, a talented athlete with a temper, joins the A.N.T. program, Lexi orders Chyna to keep her away from her.
When Olive's pet robot, Hegel, stops working, everyone starts suspecting each other of sabotaging it.