Tom goes to see Isabelle in prison to figure out the location of Alana.
Diana is back from Spain, and Kyle learns some intriguing information about Cassie.
Shawn makes up his mind to resume his healing venture at the 4400 center, in opposition to the government's admonitions.
April, Diana's sister, remains alive after a promicin shot and is now able to make anyone respond honestly to any question she asks.
Tom is after Kyle after learning that he is Promicin Positive ("P+"), and Maia sees disturbing visions related to 4400s and P+es.
Tom and Diana find out that Curtis Peck is missing, after he was working on a new movie that will expose a major conspiracy.
Shawn's reputation is threatened when he sleeps with the daughter of a lady whom he was able to cure.
The lives of Tom, Diana, and the others are at stake because of a lockdown at NTAC as they wakeup without any memory of the reason of them being there.
As Tess's schizophrenia is no longer possible to manage, Shawn is required to help.
NTAC is tracking Richard and Isabelle down. Meanwhile, promicin is put to test to reveal whether it is deadly or not.
Tom and Diana find a man who has threatened a major tech firm due to faulty ATMs.
Marco tries to retrieve the old Tom back, but he gets into trouble, and they're running out of time.
Danny Farrell spreads promicin via a new method, which ends the lives of numerous people.