Meredith struggles to figure out what she wants as her matchmaker patient tries to steer her towards a new relationship. Teddy unwittingly reveals her pregnancy. Jo and Alex's honeymoon turns out to be nothing like they imagined.
Maggie and Jackson's relationship faces a hurdle. Bailey struggles to make a decision about who to make interim chief. Jo pursues a job opportunity. Meredith makes a decision about her love life.
As Alex struggles to adjust to his new role as interim chief, Jo and Bailey clash over the latter's inability to live up to her deal with Jo. Maggie tries to steer Amelia away from Owen to spare her the consequences of learning about Teddy's pregnancy.
Maggie struggles with the pressure of keeping Teddy's secret, which drives her to the brink. Amelia faces trouble with Betty and turns to Owen's mother for help.
As Bailey and Jo join forces to come up with a treatment plan for a difficult case, Meredith tries to help Teddy work through her animosity towards Owen. Amelia and Owen resort to drastic measures to ensure that Betty stays at school.
Meredith receives unexpected news about an estranged loved one, which brings up painful memories from the past. Bailey and Jo make a medical breakthrough.
After a consult, Catherine receives a shocking diagnosis that she worries might destabilize Richard. In the wake of a loss in the OR, Richard struggles to hang on to his sobriety.
As a storm hits Seattle, Bailey's stress mounts after the storm prevents Jo and Alex from reaching the hospital. Amelia makes a shocking decision about Betty. Teddy comes clean to Owen.
Andrew confides in Meredith about his troubled family history. Amelia, Owen, and Teddy are forced to work through their awkward situation to help a patient. The news about Catherine's cancer reaches Richard and Jackson.
Owen makes a decision regarding his love triangle with Amelia and Teddy. Meredith and Link find middle ground after a professional disagreement. Maggie worries about the effects Catherine's diagnosis might have on the family.
With Catherine's surgery underway, Bailey and Maggie step up to support Jackson and Richard, as Amelia and Koracick face complications in the OR. Meredith makes a difficult decision to reconnect with her dying father.
Owen and Amelia discover that Betty has been keeping a major secret from them. Inspired by a case, Andrew makes a move on Meredith. Catherine struggles with the outcome of her surgery.
Owen battles his fears about losing custody of Leo when Betty's parents arrive in Seattle. Maggie has trouble with a case when the patient turns out to be a former bully of hers.
As Owen struggles to accept the loss of Leo, Betty's life hangs in the line after an overdose causes complications. More cracks appear in Maggie and Jackson's relationship.
As Jackson throws a party to celebrate the success of Catherine's surgery, the troubled personal lives of the doctors sends the party spiraling into chaos.
As Andrew's father prepares a medical pitch for Alex, Meredith faces a difficult choice between warning her friend or keeping Andrew's confidence. Amelia makes a decision regarding Leo's custody.
Andrew and Carina clash over their father's mental health. Jo makes a decision to seek her birth mother. On Bailey's advice, Alex confronts his mother about her long stay in Seattle.
Andrew struggles to work through the aftermath of his father's breakdown. Tensions rise between Owen and Koracick after Teddy starts having contractions.
In the wake of Jo's meeting with her mother, she shuts Alex out and tries to deal with the shocking truth she received on her own. However, a new case forces her to dwell on what her birth mother has told her.
The arrival of Megan Hunt sends Owen and Teddy into a spin as Megan learns about the status of their relationship and the pregnancy. Link's attempt to reach out to Jo is thwarted when he learns of the extent of her struggles.
Amelia is forced to confront her estranged family when she makes the trip to New York for a surgery. As she gets Link to pretend to be Owen, the family dinner quickly spirals into chaos as old resentments are brought to the surface.
As Jo continues to spiral, Richard is shocked when an old friend is rushed to the hospital after falling off the wagon. Owen seeks treatment to deal with lingering trauma from the past.
In an attempt to help a patient, Meredith makes a shocking move that might threaten her career. Jo's downward spiral leaves a patient and his family disappointed after a misunderstanding.
As the doctors scramble to save Gus, Meredith steps in to try and help Jo move on from what happened with her birth mother. Andrew takes a daring step to protect Meredith when her insurance fraud gets discovered.
With Teddy in labor, Amelia steps in to help her reach the hospital. Maggie is left alone as Jackson disappears into the fog. Meredith takes responsibility for her actions. Jo finally accepts that she needs help.