Ava pulls out all the stops to ensure that Connor stays in Chicago. Goodwin butts heads with the hospital's new COO. Dr. Charles deals with the aftermath of his actions with Dr. Reese's father.
As the ED receives an influx of patients after an apartment fire, Will faces a personal dilemma when his own father is rushed to the hospital. Connor faces pressure when he becomes the only thing standing between a firefighter and losing her career.
Ethan is forced to choose between obeying the law and saving his patient's life. Connor recruits Maggie to assist him in the hybrid OR.
Will gets embroiled in a CPD investigation after getting involved with a shady wedding hall owner. Natalie deals with an undocumented patient.
Will hides the truth about his involvement in an undercover operation from Natalie. Ethan is shocked when he finds out damaging information about Emily's boyfriend.
Will and Natalie team up to help a patient whom they suspect is being abused. Connor and Lanik clash over the latter's treatment of med students. Ethan and Dr. Charles stumble upon a secret about one of their patients.
A chemical spill causes tensions to rise in the ED as one of their own lands in peril. Connor discovers the truth about his father's involvement with the hybrid OR.
Will's involvement with the FBI puts a strain on his relationship with Natalie as he continues to lie to her. Ethan clashes with Dr. Charles on how to handle a mentally ill patient.
Will and Natalie's wedding day takes an unexpected turn when Will is kidnapped and exposed as an informant for the FBI.
Tensions rise between Connor and his father after Ava tells the former that his father is spreading lies about her. A drive-by shooting leaves April injured and pushes Ethan to the brink as he is forced to treat the shooter.
The effects of Will's ordeal lead him to take drastic actions with a patient. A case hits too close to home for Ethan as he deals with a homeless veteran.
When Elsa takes the outcome of a case hard, April steps in to console her. Will rushes to Natalie's side when her chopper crash lands.
Trust issues boil over between Will and Natalie, especially after he hides the theft of his gun from her. A risky operation on an HIV patient takes a turn when Ava faces the possibility of infection.
When a familiar face returns to the ED, a guilt-stricken Maggie takes drastic actions to help. Will continues to spiral as someone connected to him lands in the hospital with a gunshot wound.
Natalie and Maggie jump in to perform triage after a truck crashes through a festival. Dr. Charles recieves unexpected news about his family as Connor deals with Robin's return.
The conflict between Ava and Connor escalates after she challenges his refusal to operate on Robin's mother. Ethan and April deal with a heartbreaking case in which a brother is being used as a constant donor to his cancer-stricken brother.
The ED is shaken when a car crashes through the doors, leaving the life of one of their own on the line, and forcing Ethan to make a difficult choice.
Connor deals with a dangerous situation involving Robin. Natalie and Ethan clash over an issue that involves doctor-patient confidentiality and parental consent.
As Connor receives troubling news about his father, the two are forced to reevaluate their relationship. Chaos ensues at the hospital when a gunman holds everyone hostage to prevent his girlfriend from giving their baby away.
Ethan is forced to put his feelings about Emily's boyfriend aside when he lands in the ED as a patient. Connor confronts Ava about his suspicions. Natalie and Dr. Charles are at odds over the proper treatment of a cultist who is harming herself.
Will faces a difficult decision when he discovers a disturbing fact about Maggie's sister. Ethan and April are left to deal with Emily's sudden decision to walk out on her baby. Connor gets difficult news.
Connor grows suspicious of the circumstances of his father's death. Maggie recieves some bad news. Agent Lee shares some news with Natalie that cause her to reevaluate her relationship with Will.