Dr. Meredith Grey is a surgical intern who starts her new job at Seattle Grace. When she falls for her attending Dr. Derek Shepard, she must face the personal and professional challenges of having a relationship with her superior, as she adapts to her new work environment.
In this season, Meredith returns to her old house and attempts to adjust to life with Amelia and Maggie. The doctors at Grey Sloan Memorial Hospital attend to two fifteen-year-old girls after being engaged in a railway accident. Meanwhile, Jackson is getting ready for April's return.
As a new disaster occurs at the hospital while everyone is troubled carrying their own secrets and fears, things unfold unexpectedly, throwing the doctors for a loop as they try to hold it together to save lives and save their institution.
The team at Grey Sloan Memorial bands together to help Owen's sister after her shocking return. Andrew's sister Carina pitches a new research idea to Bailey with shocking consequences.
As Meredith struggles to make a decision regarding her love life, Teddy's presence in Seattle raises the tension between Owen and Amelia, who are forced to reexamine their feelings for each other.
Meredith, Richard and Alex must deal with the fallout after their insurance fraud is discovered and Bailey fires them.
When COVID-19 pandemic hits Grey Sloan Memorial and affects everyone on the personal and professional level, the hospital surgeons have life-changing decisions to make.