James "Ghost" St. Patrick, is a rich New York nightclub owner, who caters to the city's elite but runs a narcotics ring.
In the second season, Ghost tries to find out the truth from information he finds about the attempted murder, and Tommy disappears after discovering that Angela is with the FBI.
In the third season, it turns out that Lobos is still alive, and Ghost part ways with Tommy, as Tommy begins working for Lobos. On the other hand, Ghost tries to deal with a new competitor.
In the fourth season, after Ghost is arrested for the murder of Agent Knox, Ghost faces many threats from many sides, and federal agents try to build a coherent case against him.
In the fifth season, Ghost forms a strong alliance with Tommy and his arch-rival Kanan. Angela is involved in a murder and also becomes an ally, and the events develop with the death of Raina.
In Season 6, Ghost decides to take revenge on Tommy Egan, and Tasha vows to settle her score with Ghost sooner or later after Terry Silver is killed.