Neurosurgeon Christopher Duntsch performs surgery at a Dallas hospital, but leaves two patients seriously injured and one dead. Dr. Henderson and Dr. Kirby investigate what Duntsch did and his motives.
Henderson and Kirby uncover Duntsch's history of medical misadventures and decide to strip him of his medical license. As a young man, Duntsch tries out for an American football team, wavering between football and medicine.
Duntsch studies under a renowned neurosurgeon and seeks a patent for his stem cell research, while Henderson and Kirby reveal how the liability of the medical system has allowed Duntsch incompetence to persist in Texas.
Henderson and Kirby crash an event held in Duntsch's honor. Duntsch moves to Texas, establishes his own practice, and is recruited by one of the country's leading hospitals.
Duntsch begins his work in Dallas and the medical mishaps immediately pile up, while Henderson and Kirby gain a legal ally to stop Duntsch before he can do more harm.
Duntsch tries to fix a catastrophic surgery on a friend of his, while Henderson and Kirby offer their expertise to Michelle Shughart to build her case against Duntsch.
Duntsch is arrested and tries to defend himself, while Henderson and Kirby stumble upon a terrible conflict of interests in Duntsch's past, and Shughart seeks answers to lingering questions.
Duntsch faces trial after maiming or killing thirty-three of his thirty-eight patients, while Henderson and Kirby suffer from the failure of the medical system.