General Fasoose enlists MacGruber for one more suicide mission after he served eleven years in prison for the murder of his old adversary.
MacGruber needs to get away from his captor, Brigadier Commander Enos Queeth, or else he will be tortured.
Before the bad guys can obtain the deadly chemical weapon Brimstone, MacGruber and the team must hurry to recover it.
MacGruber and the team make a daring plan to go undercover at a party in Miami to prevent Queeth from carrying out his plan.
As Vicki gets closer to obtaining the Brimstone from the scientist Irina Poliskya, MacGruber stands in her way.
MacGruber launches a retaliatory attack on Queeth's enormous compound while the team is in disarray.
As Queeth's evil plan continues, MacGruber must figure out who is responsible for the latest attacks.
Now that the group has reunited, MacGruber and the others battle to live and prevent imminent harm to the planet.