After his return from Vietnam, John Winchester joins forces with Mary Campbell to stand up to the monsters threatening their world, and they embark on an adventure to search for their missing fathers.
A man disappears in Topeka, so Mary is forced to temporarily stop the search for her father in order to investigate this mysterious disappearance, and the adventure leads her to face daunting challenges.
A terrifying Hindu demon kidnaps two young children from Mary's neighbors, so she sets off with John to retrieve them, and engages in a fierce confrontation to destroy this demon.
A new and mysterious case comes to the team's attention with the tragic death of a vet and strange burn marks appearing on the walls, prompting a series of investigations into the matter.
After the death of a councilman in strange and mysterious circumstances, the team suspects the involvement of the Akrida monsters in the matter, bringing about conclusions that lead to shocking confrontations.
A monster begins to pursue an old friend of Mary's mom, so the team sets out to end this suffering and eliminate the monster, but will they succeed?
Roxy offers Mary a swap for Samuel. The team attempts to summon the spirit of Henry Winchester to ask him questions, but they face more challenges.
With Samuel wounded, John, Mary, and Millie try to help him recover, while Carlos and Latika begin investigating a strange death that occurred inside a bar.
The friends find themselves face to face with vampires, while John has a frightening vision that ends with a tragic death at the hands of their leader, as he begins to worry about taking part in this confrontation.
John and Mary come across a new ally in their perilous battle against the Akrida monsters, while Carlos and Latika decide to locate one of the Akrida's previous victims.
John gets into trouble when he is arrested for Kyle's murder, while Latika finds herself forced to re-experience a bad event dating back to her childhood.
A heated discussion breaks out between Mary and John, but it ends when Carlos and Latika arrive to discuss a strange mystery surrounding a scary clown, while Ada discovers something intriguing.
The team tries to stop the Akrida attack with the help of an unexpected ally, and events bring about a series of complex challenges and bloody battles.