A ghostly couple is disturbed when a loud, obnoxious family moves into their home. When their attempt to scare them away fails, they enlist the help of a malicious spirit, Beetlejuice, to drive them away. But the plan goes south when Beetlejuice grows infatuated with the human couple's daughter.
Three generations of the Deetz family come back to their roots in Winter River following an anticipated loss. With Beetlejuice's haunting presence still looming, Lydia's life takes a turn for the worse when her teenage daughter, Astrid, accidentally unlocks the gateway to the Afterlife.