The FBI finds a girl named Jane Doe, and with their help, Jane tries to remember her past, and who she is.
FBI agents analyze Jane's tattoo and discover that it indicates an Air Force pilot with a bad past. A bad memory haunts Jane's life. Weller claims he knows who Jane is.
A member of a jewelry theft gang is arrested while performing a magic trick at a mass show. Jane receives a visit from a mysterious person from her past, but he refuses to tell her anything about it.
A tattoo mystery leads Patterson and David to the headquarters of the CDC, where they discover that Jane's body contains a mysterious secret.
While trying to rescue a hostage in a difficult situation, FBI agents find themselves in a wrong pursuit with CIA agents. Carter feels that Jane should not be trusted.
During an assassination, the team discovers that criminals are using software that enables them to monitor and track police cars. The team has to go after the creator of the app to take it down.
A tattoo on Jane leads the FBI team into a dangerous hunt against a criminal, putting the team's life in danger. Patterson attempts to solve another mysterious tattoo on Jane's body.
When a police officer is murdered, Patterson discovers an alarming tattoo that appears to have predicted his killing. Mayfair reveals the secrets of her past to Weller, which could threaten their relationship.
Jane and Weller go undercover to sneak into a black market deal. Carter and Mayfair have a new disagreement while David tries to mend his relationship with Patterson before it is too late.
Spies are starting to appear and planning several assassinations. With Jane's help, the team go in pursuit of them.
A tattoo on Jane's body leads to many dangerous discoveries and Jane wonders whether to trust Oscar or not. A new tattoo on Jane's body leads the team to discover a terrible disaster in the Black Sea.
The team interrogates a supposedly dead ex-soldier who is going on a killing spree, while Jane is seeking answers from Oscar.
After knowing that there is mole in the FBI, the team's darkest secrets are threatened to be uncovered to everyone.
Zapata goes undercover for the team when they investigate a death row case after getting an anonymous tip. Jane is thinking of leaving the FBI.
Knowing that Jane is a real target after a painting of one of her tattoos is stolen, she goes AWOL to keep her team safe.
The team discovers that an armored truck is robbed by roamers, and that the truck also contains chemical weapons, as a group of terrorists seeks to control it.
Patterson uncovers a coded message in the New York Times crossword, and Weller asks his father about who kidnapped Taylor Shaw.
Rich Dotcom decides to cooperate with the FBI to arrest Shohid Ahtar, after realizing he won't make it in prison.
During the investigation of a new tattoo, a shooting happens on a college campus and the teams runs to find the shooter. Mayfair's past haunts her.
A young girl that is connected to a tattoo, jeopardizes the team because of her connections with a terrorist organization. Borden and Patterson are bonding.
Personal conflicts arise when the team gets trapped inside the FBI building after it gets infiltrated by criminal hackers.
The team sets out to find an abandoned baby with Jane's same tattoo.
Weller searches for the painful truth while Jane and Oscar try to seek the help of a former suspect. The team races to help a friend.