When one of his mother's old students passes away, Dr. Beaumont Rosewood is recruited by his mother to look into the incident, leaving him to join forces with Det. Annalise Villa.
As Rosewood and Villa investigate a new case involving a wealthy man, the former is torn between his own wishes for the future and his mother's demands.
Rosewood and Villa have a disagreement after the latter arrests a young man whom Rosewood believes is innocent. Villa's personal life accidentally intersects with Rosewood's as she seeks a therapist, who turns out to be Rosewood's girlfriend.
Rosewood receives life-changing news. Villa clashes with Captain Hornstock who doesn't want her to pursue a case. Rosewood and Villa team up to prove the guilt of a doctor who has killed his patients.
When a former convict is killed, Rosewood and Villa pull out all the stops to find the culprit. Rosewood deals with some personal issues.
Rosewood and Villa are forced to put aside their differences and work together to prove the innocence of Captain Hornstock, who gets accused of killing an ex-wife.
Rosewood finds himself going toe-to-toe with his own father, a fellow pathologist, when they end up on opposing sides during a murder trial.
As Villa tries to reach out to her estranged mother, she and Rosewood are thrust into an unfamiliar world as their latest investigation leads them to team up with a detective-turned-bounty hunter.
Rosewood and Villa are thrust into a world of glamour when a designer seeks their help to fend off a murder attempt, leaving Rosewood to realize that he and the victim may have something in common.
While in pursuit of a serial killer, Rosewood and Villa join forces with TMI's ex-fiancé, whose return causes a lot of problems for TMI and Pippy, and also for Hornstock.
As Rosewood and Villa race to find the serial killer before another victim is killed, Hornstock realizes that there is a price tag attached to his new position as chief.
As Hornstock clashes with Villa over the choice of her new partner, the latter realizes the price Hornstock paid because of her. A new case sends shock waves through the Rosewood family.
When Villa gets partnered with a familiar face, her partnership with Rosewood becomes on the rocks, especially as he comes to suspect that Villa's new partner knows more than he is letting on.
Rosewood and Villa face a difficult situation when their informant becomes the prime suspect in a case, forcing them to confront the fact that they do not know him that well.
Rosewood lands in trouble when he unwittingly reveals the way to commit the perfect murder at a pathology convention, forcing him to recruit Villa for help when someone follows his scenario.
As Rosewood's mother and girlfriend clash over their differing opinions on his personal and medical decisions, a case hits too close to home for Rosewood and forces him to confront his own medical issues.
The death of a telenovela star forces Rosewood and Villa to examine their own relationship as they are thrust into a world of complicated relationships. Donna continues to resent Erica's influence on Rosewood's life.
As another pathologist arrives in town, he quickly impresses Villa and Hornstock, leaving Rosewood insecure about his place.
Donna recruits Michie to dig into Erica's past. Rosewood and Villa face a challenge when they are unable to identify what killed a local musician.
Rosewood and Villa are in for a surprise when the fate of their latest victim, an ATF agent, turns out to be connected to a case from 12 years ago.
A face from Rosewood's past returns to ask for his help to find a wealthy patient, only for the missing man to be found dead.
As Rosewood and Villa continue to grapple with their feelings for each other, their relationship hits a hurdle when Rosewood goes behind Villa's back for an investigation.