The doctors are brought out of the bliss left from Amelia and Owen's wedding when Andrew is rushed to the hospital. Alex and Jo deal with the aftermath of Alex's attack on Andrew. Meredith struggles to decide on what to do after the attack.
As Alex faces criminal charges, he threatens to crumble under pressure as his career and freedom hang in the balance. Jo makes a decision about her relationship with Alex.
Amelia interferes to smooth things over between Meredith and Maggie as tension grows between them over Nathan. Arizona's loyalties are divided in the aftermath of Andrew's attack.
April and Jackson come to an agreement regarding their living situation. Amelia and Owen make a decision about their future. Meredith ponders if her relationship with Nathan puts their patients in danger.
Meredith and Bailey face a dilemma when a liver that matches two patients becomes available, but a shocking decision from Bailey's patient leaves everyone reeling.
When a former Grey Sloan doctor makes a surprising return, Catherine realizes that they need to reevaluate their teaching methods. Andrew's bond with Jo takes a romantic turn.
As an education consultant arrives to oversee the training program at Grey Sloan, her presence leads several doctors to doubt themselves as her unconventional methods earn the disapproval of others.
A number of doctors are forced to confront painful memories from their past as they perform surgery on an unidentified patient.
Amelia takes a decision about her marriage. Richard comes to learn what Eliza Minnick's presence means for his job. Jo confides in Alex about her traumatic past.
Bailey, Arizona, and Jo face a difficult case involving an incarcerated teenage mother who is about to give birth in a maximum-security prison.
With Alex's decision about the plea deal unknown, Meredith tries to find him. In support of Richard, the attendings block Eliza's attempt to be present for their surgeries.
Bailey takes drastic measures to end the attendings' impediment of Eliza. Maggie's mother enlists Jackson's help with a medical issue.
Loyalties are tested and sides are chosen as the attendings clash with each other over supporting Richard or Bailey. The next phase of Eliza's plan runs into a snag that she can't handle.
Arizona's relationship with Eliza progresses. A tough call during surgery hits too close to home for Jo. Alex resents how Eliza's new technique has left him doing inferior work that is meant for residents.
Andrew gets caught in a professional disagreement between Alex and Nathan. Richard and Catherine are unable to keep their professional and personal lives separate, which puts a strain on the others.
A trip to Montana leaves Jackson to confront a painful part of his past. April and Jackson reveal that they are aware of Catherine's attempt to meddle in their relationship.
Maggie discovers the truth about her mother's condition. Stephanie has a tough case that leads her to rethink her future. Owen and Amelia have a confrontation about the status of their marriage.
The mounting pressure to figure out a way to save Maggie's mother leaves the doctors clashing over the best way to move forward. Richard has an epiphany about his relationship with Maggie.
As Maggie deals with her mother's death, her colleagues worry that she is not in the right mindset to return to work. Arizona and Nathan find a surprising connection to one another.
On a plane to a conference, Nathan and Meredith are forced to put the tension between them aside to help injured passengers as the plane hits heavy turbulence.
April and Bailey join forces to reconcile Catherine and Richard. A former patient of Alex gains a surprising ally in the form of Amelia after her health goes downhill.
A difficult case inspires Meredith to do what is right for herself and take a chance with Nathan. Richard voices surprising support of Eliza's judgment of Ben's work.
Owen gets shocking news about his sister. The doctors make a late discovery about the true identity of one of their patients, leaving one of their own in peril.
With Grey Sloan aflame, Stephanie struggles to stay alive and save her patient, but hope dwindles as the rest of the staff desperately tries to reach her. Meanwhile, Owen and Amelia make the trip to reunite the former with his sister, Megan.