In Sinaloa, Mexico Teresa Mendoza's life forever changes when she falls for the drug dealer Güero. But when he gets murdered, Teresa is forced to flee from his former cartel and travels to Dallas, Texas.
After she rescued Teresa in Mexico, Teresa must prove her loyalty to Camila Vargas by doing a dangerous job. In Mexico, the cartel is still looking for Brenda.
Camila tasks Teresa with a major drug operation to test her loyalty, while she plots to seize control of Epifañio's cartel. Brenda plans to escape from the cartel sicarios.
Teresa's first solo drug run takes a deadly turn. Epifañio sends Cesar to kidnap Teresa after finding out that Camila is hiding her. Brenda escapes to Dallas with Tony.
Teresa is tasked with infiltrating a party of a rival drug boss. In order to support herself and Tony, Brenda starts working for a drug dealer. Epifañio tries to sabotage Camila's network.
Camila's business is threatened following a drug bust by the DEA. Brenda and Tony's relationship is strained by her drug dealing business.
As Camila continues to lose more shipments, she suspects that there is someone double-crossing her. Teresa and James run into trouble as they're sent to recover a stash of savings. Brenda's power grows bigger.
Camila is forced to resort to dangerous measures after running out of options. Teresa must make a life-altering choice as she goes undercover. Brenda switches to a more risky product.
Camila tells her partners that she's back in the game as Epifañio is out of the picture. Teresa helps a witness named Maria escape, and they both travel to Mexico.
Teresa tries to look for Güero's notebook. In an attempt to keep herself safe, Camila returns to Mexico. James continues to look for Teresa.
Camila's operation must go underground after she teams up with the Jimenez cartel. Teresa and Brenda want to start over now that they have Güero's notebook.
Teresa and Brenda make a dangerous extortion attempt. Camila makes a bold move to overtake Epifañio's empire.
Teresa risks everything to protect the book and save Brenda. Epifañio discovers new information that changes everything.