Three months after the accident, Max tries to readjust to his new life as a father. Iggy makes a decision that could drastically change his life. Bloom struggles with the effects the accident left on her.
Max tries to figure out a way to get the overworked staff to have time for themselves and their families. Kapoor worries about Max's state of mind in the wake of Georgia's death.
Sharpe clashes with a medical device company over the risks of their hip prosthetics. Max gains another ally in the form of his new assistant. Iggy and Kapoor try to figure out the source behind a unit-wide outbreak.
Max is forced to compromise after his attempts to help the local African-American community leads to unintended consequences. Iggy and Kapoor find themselves in over their heads when they discover that the city caused a widespread lead poisoning.
Sharpe and Max join forces to help a cancer patient who wishes to have a baby. Iggy tries to help a troubled girl stay out of a correctional facility.
When the hospital receives the members of a congregation after a car accident, Max comes to realize that there is a tragic secret behind the accident. Sharpe and Kapoor find themselves in the middle of a family feud between two sisters, one of whom needs the other's kidney.
Sharpe discovers a cover-up by the hospital after a medical error left her patient in a wheelchair. A patient inspires Reynolds to reach out to his father.
Sharpe's efforts to help a patient land her in trouble. As Max tries to help a patient with her grief, he is forced to confront his own lingering sorrow.
Max, Iggy, and Sharpe make a visit to Rikers Island to lend a hand to the prisoners. Bloom's road to recovery proves to be turbulent.
As they try to help the prisoners, Sharpe and Max find themselves in danger after the inmates escape from their beds. Iggy confronts his issues with his husband after a fight.
Inspired by the connection he forms with another single parent, Max implements a new technique to improve communication with his patients. Iggy is pushed to the brink as he confronts his demons and another psychiatric evaluation.
As Max and Reynolds face a mystifying case, Sharpe faces the potential of a career upheaval after making an important realization.
Reynolds stands at a crossroads when it comes to his career. Max pushes for the opening of a palliative care wing in the hospital.
Max faces budget problems that leave him scrambling to provide pay for the hospital employees. Iggy puts everything on the line to prove that a diagnosis he made is correct.
Suspicious that Castro might be tampering with the results of her drug study, Sharpe becomes determined to get to the bottom of it. Max faces a huge challenge when he is asked to join the fight to combat the opioid crisis
Faced with a possible lawsuit, Max, Bloom, and Reynolds go over an encounter with a patient to figure out what happened. When he learns that a shooting drill at a school has left a girl traumatized, Iggy challenges the teaching methods at the school.
As Reynolds prepares to leave, he gets involved in a case after getting trapped in an elevator with a bleeding man. Sharpe gets close to young cancer patients when she takes part in a charity event for cancer.
Max fights to save a child's life by trying to get him into a clinical trial. Sharpe and Bloom try to figure out the source of an infection that has gotten to several patients.