With Nic struggling to overcome her grief after a personal tragedy, the rest of the hospital staff finds it hard to adapt to the new regulations set by Red Rock Mountain Medical.
In a bid for publicity, Cain sets up a dangerous surgery that requires the expertise of Bell and Kit on top of his own. AJ deals with a personal matter. Mina learns disconcerting news that might put a friend's life in danger.
Conrad learns that Jessie's death might have a different cause than what they originally thought. Nic is concerned about Cain's ethics in choosing his surgeries.
Devon confronts Conrad about the latter's tendency to cross the line in the name of helping patients. Car trouble leads AJ and Mina to learn startling information about Red Rock Medical.
Conrad and Nic's investigation into Jessie's death causes them to consider how willing they are to put their jobs on the line. Devon is consumed with guilt after withholding information that could have prevented a plane crash.
Kit is on the warpath after Cain's cavalier practices put a patient in danger. Conrad is horrified to learn that his father has taken the same drug that can be linked to Jessie's death.
As Jessica's life hangs in the balance, the staff scrambles to save her, leading to severe disagreements to rise between Cain and Conrad. Conrad gets new information about Hemopleatin, causing Cain and Red Rock VP Logan Kim to see him as a problem.
With the hospital overflowing with patients, Logan Kim continues to look for publicity stunts. AJ brings his biological and adoptive families together for the first time.
When Conrad's past actions come to haunt him, Bell is blackmailed by Red Rock to get rid of him. After a successful diagnosis, the life of Devon's real-life princess is jeopardized by Cain who botches her surgery.
As Devon says goodbye to his days as an intern, the situation at Chastain escalates as Bell makes a horrific discovery about Cain. Mina faces an uphill battle to save Adaku and her baby.
With Cain in charge, he soon makes controversial decisions that leave the patients in peril. Conrad tries to figure out what to do after getting fired.
A former patient enlists Conrad's help with a financial crisis. Cain puts the move on Bell's business partner, Andrea.
Nic tries to help a loved one from succumbing to depression. Bell and AJ make use of Conrad's diagnostic talents while treating a soccer player with a mysterious illness.
With Cain on thin ice with Kim, the staff comes together to save the lives of two of Chastain's biggest donors. Irving and Devon make a connection between three patients that might endanger Bell's supplement company.
Nic and Cain butt heads during surgery. Devon and Conrad make a discovery that might save Bell's company.
Devon tries to impress Nadine's father. Bell makes a smart maneuver to curtail Red Rock's attempt to shut down the OB/GYN department.
AJ, Devon, and Torres are forced to make a questionable decision to allow for a complicated surgery to take place. Nic and Conrad team up to save their patient, who is one of the victims of a sex trafficking ring.
As one of the victims of Cain's approach is rushed to the hospital, his investigation into the cause of her illness reveals an infection that puts all of Chastain at risk.
With Logan Kim pressuring Cain to keep silent, the ramifications of the contamination starts costing the hospital more lives, with Kit's son-in-law becoming at risk of exposure.
As a face from Cain's past arrives at the hospital, Derek faces the consequences of his infection, leaving Cain guilt-ridden. Kim makes a surprising offer to Conrad.