It turns out that the horror awaiting Coulson and the group when they become stranded aboard an enigmatic spacecraft is only the beginning.
When Coulson and the group discover they are trapped in space on an enigmatic vessel, they are taken aback.
Daisy makes the risky decision to save Simmons after she encounters a young inhuman named Abby.
Coulson and the team discover exactly what their captors' true intentions are, but in space, escape is not an option.
When Fitz's covert mission is uncovered, nothing will stop him from finding his missing squad with Lance Hunter's assistance.
Daisy, unable to flee the chaotic circumstances she finds herself in, is about to receive a surprise as an unexpected friend tries to save her.
As the group gets back together, they are ambushed by an unconquerable Kree fighter who wants to murder them all.
Coulson and the group learn that the answer to averting Earth's annihilation might lie with the most unexpected individual from S.H.I.E.L.D.'s past.
In an attempt to repel Kasius and the Kree, Mackenzie and Yo-Yo rally the humans. Kasius has equipped the lighthouse with dispersed bombs that may instantly destroy every human being.
The group has a single chance to go back in time, but it will require them to make some difficult decisions that might have dire repercussions.
Although Coulson and his group intend to alter human history, they are blind to the ways in which their actions will impact the life of a single S.H.I.E.L.D. agent.
Coulson divulges the specifics of his enigmatic agreement with the Ghost Rider, which will have an impact on every member of the group.
Deke finds out the truth about his grandparents. Hale and Ruby enlist a new team member, and the team makes a last-ditch effort to save the world by searching for Gravitonium.
While trying to figure out how to close the rift, Fitz and Simmons encounter one of their biggest nightmares.
When Coulson discovers General Hale's actual motivation, the group needs to figure out how to support her so they can save the situation.
In an effort to save the planet from peril, Coulson teams up with unexpected friends, and the SHIELD team is working feverishly to find and save him in the meantime.
Fitz, Simmons, and Yo-Yo try to eliminate a weapon that might contribute to Earth's devastation when an agent's life is in jeopardy.
Before the predicted chain reaction that can potentially kill the entire planet is set off, the crew must figure out how to stop Ruby.
When the group gets stuck and is besieged at the lighthouse, they run the risk of being attacked. Coulson quickly learns that they have been abducted and taken to a spacecraft.
Daisy gives Jemma instructions on how to use the Centipede technology while Talbot and Coulson try to negotiate with the Confederacy regarding the destruction of Earth.
Melinda and Coulson battle to escape the Confederate spacecraft. Meanwhile, Daisy's prospects are seriously jeopardized.
When a mystery man freezes them, the team's joy at their reunion is short-lived. They are suddenly forced to make a choice that might end up destroying the entire planet.