While facing a career-threatening medical diagnosis, Holmes meets Michael, a man who considers Holmes behind helping him overcome his addiction.
Holmes and Watson find themselves in pursuit of a shipment of stolen plutonium, which they suspect will be used to build a dirty bomb.
Holmes and Watson step inside the world of rare artifacts when they investigate a murder case that took place at a Revolutionary War reenactment.
Watson contemplates making a big change in her life after reading her treatment profile, while she and Holmes are investigating the murder of her previous therapist.
Sherlock finds himself in trouble with a temporary case of memory loss, while Watson helps him recover his memory.
Holmes and Watson get involved in a case of nuclear security when a former member of the Japanese crime syndicate is found killed.
Sherlock faces grave problems that get in the way of his recovery, while he and Watson track down a serial killer preying on people in Holmes' circle.
After a woman is found encased in cement, Holmes and Watson go after the killer, as they find themselves entering the world of the clean technology industry.
Holmes and Watson take on the case of poisoning of a biology professor who was involved in a secret project, while Holmes' former sobriety sponsor enlists his help to rescue his brother.
Following the death of a family member, Sherlock and his father try to mend their tense relationship, while Joan and Sherlock’s latest case takes the duo to the world of Egyptian antiquities.
Holmes and Watson look for a murderer linked to the tobacco industry when a lawyer who was handling the finances of a major cigarette distributor is killed.
After being offered a rare job opportunity, Detective Bell considers quitting the police department, while the duo take on the case of a missing woman.
Holmes and Watson take on the murder case of a relocation expert who was hiding a secret profession behind the scenes, while Watson faces obstacles regarding her adoption attempts.
While in quarantine, Gregson and Bell believe they are trapped inside the precinct with a terrorist, while the Sherlock and Joan do their best to save them.
Holmes and Watson draw up a list of possible replacements for Bell due to his upcoming departure on a long assignment, while they also handle a murder case linked to the occult.
Holmes and Watson find out that the murder of a robotics engineer may be linked to his secret teleportation research.
Holmes and Watson believe a zoologist was killed as a result of his many affairs or groundbreaking research, while Holmes becomes a victim of identity theft.
The duo handle the case of a dead man who claimed to predict future deaths, including Holmes', which are starting to happen.
Holmes and Watson are doing their best to find a missing woman, and Holmes' friend happens to be the main suspect in the woman's disappearance.
The confrontation between Holmes and Michael is on as a new victim appears, but not everything is what it appears to be.
Following Rowan's murder, Holmes races to find the killer, which puts his partnership with Watson at risk.