The staff at Chicago Med begins adapting to life in the aftermath of the pandemic. Dr. Halstead becomes wary of a patient of his, while having troubles with Hannah. Dr. Choi and April take over the COVID-19 unit.
As Sharon chooses a new head for the ED, Dr. Halstead has reservations about the choice. Dr. Manning sticks up for a patient of his against her parole officer. Dr. Charles handles some family issues.
Dr. Charles and April tend to a patient who might be a kidnap victim. Dr. Marcel is taken aback when he sees an ex of his brought to the ED. Dr. Halstead deals with a heart disease patient.
With Dr. Halstead trying to find subjects for his clinical trial, he gets unexpected help from April. Dr. Marcel and Dr. Manning risk their careers to help a patient. Dr. Choi deals with a patient who’s trying to attain the perfect body.
Dr. Choi faces a difficult situation that involves Noah, April’s brother. Dr. Halstead carries on with his drug trial. Dr. Charles deals with family trouble, whereas his daughter asks for Dr. Manning’s help.
Dr. Marcel attempts to help a cancer patient, while Dr. Choi deals with a patient who suffers from severe pain. Dr. Halstead contemplates a career-related issue. Dr. Charles worries about a problem regarding Anna.
When a patient in the clinical trial experiences complications, a distressed Halstead tries to help him. Dr. Choi goes to the hospital as a patient. Maggie discovers something concerning Auggie’s family.
Dr. Choi gives an old acquaintance from the Navy a job in the ED. Dr. Charles is forced to deal with the fact that Anna might be taken away from him. Maggie has a tough decision to make.
As Dr. Archer confronts Natalie and Marcel with their relationship, they try to work on it while performing their jobs at the hospital. Dr. Charles takes care of a patient with a nail in her foot, while Maggie connects with another.
Dr. Choi and Dr. Halstead disagree over a pregnant patient. Dr. Marcel deals with a patient who has a piece of metal in his chest and is in need of surgery.
When a tennis player comes to the hospital with heart problems, Dr. Choi is joined by Dr. Virani to treat him. April starts working in the COVID-19 unit.
While at a field call Dr. Archer suffers PTSD symptoms, which alarms Dr. Choi. When Natalie receives bad news about her mother Carol’s health condition, she goes all out to help her.
Sharon freaks out as she gets into an accident that involves a young boy, who ends up needing a major surgery. Dr. Manning gets into trouble with Dr. Halstead.
As Natalie’s mother’s health worsens, Dr. Halstead starts suspecting her of misconduct. Maggie makes a startling discovery regarding one of the med students training at the hospital.
Natalie’s mother’s health takes another turn for the worse, while Natalie and Will try to set things right. Dr. Charles deals with a patient-related problem.
As a heart becomes available, Carol’s hopes of recovery are renewed. Dr. Choi and Dr. Archer face trouble regarding a former patient. Will must deal with the ramifications of stealing the trial drug.